Complete and acceptable symptom remission in rheumatoid arthritis: Patient Acceptable Symptom State (PASS)-based thresholds derived from the Okomarigoto Sheet
Authors' conclusion
OS-defined symptom remission provides a clinically meaningful framework for evaluating acceptable residual symptom burden in RA.
Study context
- Population
- Patients with RA, including those in Simplified Disease Activity Index (SDAI) remission213 in SDAI remission
- Participants
- 370 patients
- Outcome
- OS thresholds for residual symptoms anchored to PASS
Methodological details75th percentile method, ROC analysis, PASS as external anchor
- 75th percentile method
- ROC analysis
- PASS as external anchor
Main finding
As reported in the abstract
Okomarigoto Sheet (OS) threshold, overall cohort
3
OS threshold, SDAI remission
2
AUC for PASS, overall cohort
0.824
AUC for PASS, SDAI remission
0.838
Observational data: associations, not effects.
Further findings
Patients reporting PASS
- Patients reporting PASS, overall
- 284
Proportion reporting PASS across increasing OS categories, overall cohort
- Proportion reporting PASS by increasing OS category
- 95.2%, 83.9% and 46.8%; P < 0.0001
Proportion reporting PASS across increasing OS categories, SDAI remission subgroup
- Proportion reporting PASS by increasing OS category
- 99.0%, 95.7% and 71.4%; P < 0.0001
Health Assessment Questionnaire-Disability Index (HAQ-DI) and patient global assessment (PGA)
- Lower OS scores associated with better physical function and lower PGA scores
Original publication
Complete and acceptable symptom remission in rheumatoid arthritis: PASS-based thresholds derived from the Okomarigoto Sheet. Rheumatology (Oxford). Published 9 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →