The Association Between Quadriceps Strength and Synovitis in Knee Osteoarthritis: An Exploratory Study From the Osteoarthritis Initiative
Authors' conclusion
Higher baseline quadriceps strength was negatively associated with changes in effusion-synovitis-but not in Hoffa-synovitis-especially in the population with existing effusion-synovitis.
Study context
- Population
- Adults from the Osteoarthritis Initiative (OAI) cohort with or at risk of knee OA; knees with complete isometric quadriceps strength and effusion-synovitis and Hoffa-synovitis assessments
- Participants
- 1,513 knees
- Outcome
- Association of baseline quadriceps strength with changes in effusion-synovitis and Hoffa-synovitis (MRI OA Knee Score)
- Follow-up
- 1-year and 2-year follow-ups
Methodological detailsexploratory, longitudinal, generalized estimating equations, multivariable analyses
- Exploratory
- Longitudinal
- Generalized estimating equations
- Multivariable analyses
Main finding
As reported in the abstract
Baseline quadriceps strength vs baseline effusion-synovitis and follow-up changes in effusion-synovitis (whole population)
Negative association with baseline effusion-synovitis and follow-up changes in effusion-synovitis, OR
0.77-0.86
Observational data: associations, not effects.
Further findings
Follow-up changes in effusion-synovitis in the population with existing effusion-synovitis (stratified by synovitis-driven inflammatory phenotype)
- Significant association of baseline quadriceps strength with follow-up changes in effusion-synovitis, OR
- 0.75-0.79
- Not significant for Hoffa-synovitis
Original publication
The Association Between Quadriceps Strength and Synovitis in Knee Osteoarthritis: An Exploratory Study From the Osteoarthritis Initiative. J Rheumatol. Published 15 December 2022. doi:10.
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