Lupus & antiphospholipid syndrome
Th1/Th2 associated transcription factors and cytokines in pregnancies with systemic lupus erythematosus
Authors' conclusion
Our work indicates that in SLE patients Th1/Th2 shift is blocked with up-regulation of Th1 cell function and insufficient Th2 polarisation during pregnancy, which may be involved in adverse pregnancy outcomes.
Study context
- Population
- Pregnant patients with systemic lupus erythematosus (SLE) and healthy age-matched women, September 2021 to March 2022
- Participants
- 25 vs 22
- Comparison
- Pregnant patients with SLE vs healthy age-matched pregnant women
- SLEn = 25
- Healthy controlsn = 22reference
- Outcome
- Expression of Th1 (T-bet, IFN-γ) and Th2 (GATA3, IL-4) transcription factors and cytokines in peripheral blood mononuclear cells by real-time quantitative RT-PCR
- Follow-up
- During pregnancy
Methodological detailsage-matched healthy controls, prospective enrolment September 2021 to March 2022
- Age-matched healthy controls
- Prospective enrolment September 2021 to March 2022
Main finding
As reported in the abstract
whole pregnancy
- IFN-γ mRNA significantly higher in SLE
- p<0.001
- T-bet/GATA3 relative expression significantly higher in SLE
- p<0.05
- IFN-γ/IL-4 relative expression significantly higher in SLE
- p<0.05
- GATA3 expression lower in SLE
- p<0.01
Observational data: associations, not effects.
Further findings
Th1/Th2 transcription factors and cytokines, SLE vs healthy, 3rd trimester
- IFN-γ mRNA significantly higher in SLE
- P < 0.05
- T-bet/GATA3 relative expression significantly higher in SLE
- P < 0.01
- IFN-γ/IL-4 relative expression significantly higher in SLE
- P < 0.05
- GATA3 expression lower in SLE
- P < 0.05
Correlations
- T-bet and IFN-γ, r=0.492
- P < 0.05
- T-bet/GATA3 and IFN-γ/IL-4, r=0.482
- P < 0.05
Original publication
Th1/Th2 associated transcription factors and cytokines in pregnancies with systemic lupus erythematosus. Clin Exp Rheumatol. Published 3 May 2024. doi:10.
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