Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease
Authors' conclusion
NSAIDs are used by a minority of patients with IBD, with decreasing prescription rates over time despite high rates of opioid use and a doubling of musculoskeletal complaints.
Study context
- Population
- Adult and pediatric inflammatory bowel disease (IBD) patients, administrative claims data 2000–2022
- Participants
- 361,025 participants
- Outcome
- Temporal trends in prescription NSAID and opioid fills per calendar year, and factors associated with NSAID fill
Methodological detailsadministrative claims data, generalized estimating equation models, Wilcoxon-Cuzick test of trend
- Administrative claims data
- Generalized estimating equation models
- Wilcoxon-Cuzick test of trend
Main finding
As reported in the abstract
Proportion prescribed NSAIDs over time · 2000–2022
- Significant decreasing trend in proportion prescribed nonsteroidal anti-inflammatory drug (NSAIDs) over time
- P < 0.01
Observational data: associations, not effects.
Further findings
Factors independently associated with NSAID fill (multivariable model)
| OR (95% CI) | ||
|---|---|---|
| Opioid prescription | 2.13 (2.11–2.15) | |
| Osteoarthritis diagnostic code | 1.57 (1.55–1.59) | |
| Unspecified joint pain | 1.54 (1.52–1.56) | |
| 0.512Odds ratio (log scale) |
- Age <18 or ≥80 years associated with significantly lower odds of NSAID fill
Original publication
Temporal Trends in and Associations With Nonsteroidal Anti‐inflammatory Drug Prescription in Adult and Pediatric Patients With Inflammatory Bowel Disease. Arthritis Care Res (Hoboken). Published 17 December 2025. doi:10.
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