Musculoskeletal manifestations in children with inflammatory bowel disease: a multicenter cohort study (GASTROREUM study)
Authors' conclusion
Most patients with pIBD and arthritis presented with peripheral oligoarthritis affecting lower limb joints. A positive ANA status and development of polyarthritis predicted sustained arthritis activity.
Study context
- Population
- Patients aged < 18 years with pediatric-onset IBD and musculoskeletal (MSK) manifestations, followed for at least one year, 25 Italian pediatric rheumatology centres125 with arthritis
- Participants
- 180 patients
- Exposure
- Crohn’s disease (CD) vs ulcerative colitis (UC) vs IBDU
- CDn = 111
- UCn = 55
- IBDUn = 14
- Outcome
- Characterisation of MSK manifestations and predictors of persistently active arthritis one year after pIBD diagnosis
- Follow-up
- One year after pIBD diagnosis
Methodological detailsmulticentre, multivariable analysis
- Multicentre
- Multivariable analysis
Main finding
As reported in the abstract
Predictors of persistent active arthritis at year 1 after pIBD diagnosis (multivariable)
Antinuclear antibody (ANA) positivity, OR
3.05
95% CI 1.05–8.89
Polyarticular course of arthritis, OR
3.42
95% CI 1.13–10.38
Observational data: associations, not effects.
Further findings
- MSK symptoms prior to pIBD diagnosis — CD
- 51.4%
- MSK symptoms prior to pIBD diagnosis: UC/IBDU 40.6%
Most frequent MSK manifestations
- Arthralgia
- 72.8%
- Arthritis
- 69.4%
Arthritis distribution (125 patients with arthritis)
- Peripheral arthritis
- 76.8%
- Axial disease
- 14.4%
- Both peripheral and axial
- 8.8%
Articular pattern
- Oligoarthritis
- 52.0%
- Monoarthritis
- 26.4%
- Polyarthritis
- 21.6%
- Most frequently affected joints: knee, ankle, hip
Original publication
Musculoskeletal manifestations in children with inflammatory bowel disease: a multicenter cohort study (GASTROREUM study). Pediatr Rheumatol Online J. Published 10 October 2025. doi:10.
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