Temporal evolution of publication bias in drug safety assessment: A case study on association between osteonecrosis of the jaw and bisphosphonates
Authors' conclusion
Although publication bias decreased over time, its impact persisted for 17years.
Study context
- Population
- Studies assessing the association between bisphosphonates and osteonecrosis of the jaw, published 2006–202544 studies
- Comparison
- Bisphosphonates and osteonecrosis of the jaw (ONJ): publication-bias-adjusted vs crude OR, year by year
- Outcome
- Impact of publication bias over time, quantified as ratio of odds ratios (ROR = ORadjusted/ORcrude)
Methodological detailsfunnel plots and Egger's test, trim-and-fill adjustment
- Funnel plots and Egger's test
- Trim-and-fill adjustment
Pooled result
As reported in the abstract
ROR (ORadjusted/ORcrude) over time
Ratio of odds ratios (ROR) in 2008 (overestimation of 58%)
0.42
ROR in 2025 (overestimation of 34%)
0.66
Further pooled results
Residual publication bias by indication (subgroup)
- Stronger residual bias in non-cancer indications
Original publication
Temporal evolution of publication bias in drug safety assessment: A case study on association between osteonecrosis of the jaw and bisphosphonates. Joint Bone Spine. Published 16 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →