Risk comparison of osteonecrosis of the jaw in osteoporotic patients treated with bisphosphonates vs. denosumab: a multi-institutional retrospective cohort study in Taiwan
Main finding · ONJResult — go to the resultHazard ratio 0.581 95% CI 0.33–1.04Authors' conclusion
In osteoporotic patients, after 2 years of use, the likelihood of ONJ being induced by denosumab is lower than that of BPs, and the difference increases with time.
Study context
- Population
- Patients aged > 40 years with osteoporosis, January 2010–December 2018, multiple institutions in Taiwan3,665 per group after propensity score matching (PSM)
- Participants
- 8,962 patients
- Exposure
- Denosumab vs bisphosphonates in osteoporosis
- Denosumabn = 3,665
- Bisphosphonates (BPs)n = 3,665reference
- Outcome
- Long-term risk of ONJ
Methodological detailsmulti-institutional, propensity score matched (1:1), Cox proportional hazards model, Kaplan-Meier method
- Multi-institutional
- Propensity score matched (1:1)
- Cox proportional hazards model
- Kaplan-Meier method
Main finding
ONJ
Hazard ratio
0.581
95% CI 0.33–1.04
P = 0.07
By group
Denosumabvs BPs
HR 0.581 (95% CI 0.33–1.04); P = 0.07
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Cumulative incidence of ONJ, first and second years of drug use | P = 0.062 |
| Cumulative incidence of ONJ, from the third year onwards | P = 0.022 |
Cumulative incidence of osteonecrosis of the jaw (ONJ), first and second years of drug use
- Cumulative incidence rates similar in both groups
Cumulative incidence of ONJ, from the third year onwards
- Cumulative incidence rates significantly different
Severity of ONJ
- Not significantly different between the two groups
Original publication
Risk comparison of osteonecrosis of the jaw in osteoporotic patients treated with bisphosphonates vs. denosumab: a multi-institutional retrospective cohort study in Taiwan. Osteoporos Int. Published 16 June 2023. doi:10.
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