Causal relationship between type 2 diabetes mellitus and bone mineral density: a Mendelian randomization study in an East Asian population
Main finding · Osteoporosis risk (IVW, main analysis)Result — go to the resultOdds ratio 0.92 95% CI 0.86–0.99Authors' conclusion
T2DM is not associated with reduction in BMD in terms of genetic polymorphism in East Asian populations.
Study context
- Population
- East Asian populations: BioBank Japan GWAS summary data (T2DM, osteoporosis) and heel bone mineral density (BMD) GWAS data from ieu open gwas projectT2DM: 36,614 cases, 155,150 controls
- Comparison
- Genetically predicted T2DM and osteoporosis risk and heel BMD
- Outcome
- Osteoporosis risk; heel BMD (second outcome)
Methodological detailstwo-sample, GWAS summary data, inverse variance-weighted analysis, MR-Egger and weighted median, sensitivity analyses (Cochran's Q test, MR-Egger regression, leave-one-out)
- Two-sample
- GWAS summary data
- Inverse variance-weighted analysis
- MR-Egger and weighted median
- Sensitivity analyses (Cochran's Q test, MR-Egger regression, leave-one-out)
Main finding
Osteoporosis risk (IVW, main analysis)
Odds ratio
0.92
95% CI 0.86–0.99
P = 0.016
T2DM
OR 0.92 (95% CI 0.86–0.99); P = 0.016
As reported in the abstract
Further findings
Heel BMD (higher BMD, inverse variance-weighted (IVW))
| OR (95% CI) | P value | ||
|---|---|---|---|
| T2DMIVW | 1.25 (1.06–1.46) | P = 6.49 × 10-3 | |
| 0.512Odds ratio (log scale) |
Original publication
Causal relationship between type 2 diabetes mellitus and bone mineral density: a Mendelian randomization study in an East Asian population. Osteoporos Int. Published 12 June 2023. doi:10.
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