Urinary pentosidine level is associated with the risk of fracture in community-dwelling older adults: a prospective observational study
Authors' conclusion
High urine pentosidine levels and a history of fracture in adulthood are independent risk factors for fracture occurrence in community-dwelling older adults.
Study context
- Population
- Community-dwelling older adults, participants of the Good Aging and Intervention Against Nursing Care and Activity Decline study in 2016182 analysed
- Participants
- 254 adults
- Exposure
- Fracture vs fracture during follow-up
- Outcome
- Factors associated with fragility fracture occurrence
- Follow-up
- 5-year follow-up
Methodological detailsprospective observational, 5-year follow-up, multivariate analysis
- Prospective observational
- 5-year follow-up
- Multivariate analysis
Main finding
As reported in the abstract
Factors independently associated with fracture occurrence (multivariate analysis)
- History of fracture in adulthood independently and significantly associated with fracture occurrence
- Urinary pentosidine levels independently and significantly associated with fracture occurrence
- 23 patients experienced 24 new fractures
Observational data: associations, not effects.
Further findings
Univariate analysis: factors differing between fracture (+) and fracture (-)
- Sex, height, weight, history of fracture in adulthood, baseline grip strength, muscle mass, bone density, urinary pentosidine and IGF-1 significantly different
Original publication
Urinary pentosidine level is associated with the risk of fracture in community-dwelling older adults: a prospective observational study. Osteoporos Int. Published 8 June 2023. doi:10.
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