Prevalence and determinants of vertebral fractures in a systemic lupus erythematosus (SLE) cohort
Study context
- Population
- Patients with SLE, single centre
- Participants
- 106 patients
- Outcome
- Prevalence of vertebral fractures and their associations with demographic, disease-related and therapy-related factors
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
Prevalence of vertebral fractures in SLE
Radiographic vertebral fractures (overall prevalence)
21.7%
Clinical vertebral fractures
14.2%
New, previously undiagnosed radiographic vertebral fractures detected at vertebral fracture assessment (VFA) screening
14.2%
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Clinical vertebral fractures (reported) | SLE 14.2% |
| New, previously undiagnosed radiographic vertebral fractures at VFA screening | SLE 14.2% |
Determinants of vertebral fractures
- Older age, longer disease duration, cumulative glucocorticoid (GC) dose and lower BMD significantly associated with vertebral fractures
- Cumulative GC dose had the strongest association with vertebral fractures
Number of vertebral fractures on VFA vs cumulative GC dose (positive association)
- β
- 0.025
- p
- P = 0.025
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prevalence and determinants of vertebral fractures in a SLE cohort. Lupus Sci Med. Published 14 September 2025. doi:10.
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