Vasculitis & polymyalgia rheumatica
Takayasu arteritis and large-vessel giant cell arteritis in Italian population. Comprehensive analysis from a single institutional cohort of 184 cases
Authors' conclusion
Patients with TAK and LV-GCA show a number of similarities and also differences.
Study context
- Population
- Italian patients with TAK or large vessel-giant cell arteritis (LV-GCA) diagnosed 1996–2016, Reggio Emilia Hospital92% followed ≥24 months
- Participants
- 59 vs 127
- Exposure
- TAK vs LV-GCA
- TAKn = 59
- LV-GCAn = 127reference
- Outcome
- Clinical and imaging characteristics and outcomes
Methodological detailsmonocenter, literature review
- Monocenter
- Literature review
Main finding
As reported in the abstract
Clinical characteristics at presentation · diagnosis
- LV-GCA: higher prevalence of males
- p = 0.003
- LV-GCA: more cranial symptoms
- p = 0.001
- LV-GCA: more fever ≥38 °C
- p = 0.007
- LV-GCA: more PMR
- p = 0.001
- LV-GCA: more hypertension
- p = 0.001
- LV-GCA: higher ESR at diagnosis
- p = 0.0001
- TAK: longer delay to diagnosis
- p = 0.048
- TAK: more loss of pulses of large arteries
- p = 0.0001
- TAK: more vascular bruits
- p = 0.001
- TAK: more limb claudication
- p = 0.003
- TAK: more MI/angina
- p = 0.03
- TAK: more hypertension induced by renal artery stenosis
- p = 0.001
Observational data: associations, not effects.
Further findings
Treatment
- TAK: higher total cumulative prednisone dose
- P = 0.0001
- TAK: higher 1-year cumulative prednisone dose
- P = 0.001
- TAK: longer prednisone therapy
- P = 0.008
- TAK: more traditional immunosuppressants
- P = 0.0001
- TAK: more biological agents
- P = 0.0001
Outcomes during follow-up
- TAK: more flares
- P = 0.001
- TAK: more new vascular procedures
- P = 0.0001
- No differences for long-term remission
Imaging at diagnosis
- TAK: more vascular stenosis/occlusion
- P = 0.0001
- TAK: more vessels with structural damage per person
- P = 0.0001
- LV-GCA: more inflamed vessels per person
- P = 0.0001
- LV-GCA: more thoracic aorta involvement
- P = 0.024
- LV-GCA: more abdominal aorta involvement
- P = 0.007
- LV-GCA: more axillary artery involvement
- P = 0.018
- LV-GCA: more iliac artery involvement
- P = 0.002
- LV-GCA: more femoral artery involvement
- P = 0.0001
- TAK: more brachiocephalic artery involvement
- P = 0.011
- TAK: more celiac artery involvement
- P = 0.019
- TAK: more mesenteric artery involvement
- P = 0.019
- TAK: more renal artery involvement
- P = 0.005
- TAK: more arterial damage, common carotid
- P = 0.0001
- TAK: more arterial damage, brachiocephalic
- P = 0.006
- TAK: more arterial damage, subclavian
- P = 0.0001
- TAK: more arterial damage, descending aorta
- P = 0.022
Imaging during follow-up
- TAK: more new vascular stenosis/occlusion
- P = 0.0001
- TAK: more new vascular thickening
- P = 0.002
- No differences for new dilatation/aneurysm
Original publication
Takayasu arteritis and large-vessel giant cell arteritis in Italian population. Comprehensive analysis from a single institutional cohort of 184 cases. Semin Arthritis Rheum. Published 8 February 2023. doi:10.
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