Vasculitis & polymyalgia rheumatica
Prognostic factors in giant cell arteritis associated aortitis with PET/CT and CT angiography at diagnosis
Authors' conclusion
Positivity of both CTA and FDG-PET/CT for GCA-related aortitis was associated with an increased risk of relapse.
Study context
- Population
- Giant-cell arteritis (GCA) patients with aortitis at diagnosis, each undergoing both CT-angiography (CTA) and FDG-PET/CT at diagnosis (mean age 67±8 years; 77% female)
- Participants
- 82 patients
- Exposure
- Aortitis on both CTA and FDG-PET/CT vs aortitis on FDG-PET/CT only
- Ao-CTA+/PET+n = 64
- Ao-CTA-/PET+n = 17reference
- CTA onlyn = 1
- Outcome
- Relapse
- Follow-up
- During
Methodological detailsmulticenter, centralized image review
- Multicenter
- Centralized image review
Main finding
As reported in the abstract
At least one relapse
P = 0.019
- Overall, patients with at least one relapse
- 51 (62%)
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Risk of relapse with aortitis on CTA (multivariate analysis)Multivariate analysis | 2.90 | P = 0.03 |
Original publication
Prognostic factors in giant cell arteritis associated aortitis with PET/CT and CT angiography at diagnosis. Semin Arthritis Rheum. Published 8 February 2023. doi:10.
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