Lupus & antiphospholipid syndrome
T-bet expression in B cell subsets: Association with T peripheral helper cells and clinical activity in systemic lupus erythematosus
Authors' conclusion
Our findings provide new insights into the cooperative expression of IL-21/IL-21R and T-bet and their potential relationships with extrafollicular B-cell responses in SLE.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and healthy subjects
- Participants
- 40 vs 15
- Exposure
- SLE vs healthy subjects
- SLEn = 40
- Healthy subjects (HS)n = 15reference
- Outcome
- cTfh, Tph and B cell subsets by flow cytometry
Methodological detailsmultiparameter flow cytometry
- Multiparameter flow cytometry
Main finding
As reported in the abstract
- Increased frequency of cTfh PD-1vh, HLA-DR+, IL-21R+, and Tph PD-1vh, HLA-DR+, and iIL-21+ cells in SLE
- aNAV T-bet+ cells expanded in SLE
- Activated T-cell states (iIL-21+/IL-21R+/PD-1vh/HLA-DR+) correlated with T-bet+ B cell subsets
- Activated cTfh/Tph and atypical memory B cells (aMBCs) correlated with SLEDAI-2K
Observational data: associations, not effects.
Original publication
T-bet expression in B cell subsets: Association with T peripheral helper cells and clinical activity in systemic lupus erythematosus. Lupus. Published 2 July 2026. doi:10.
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