Lupus & antiphospholipid syndrome
Systemic lupus erythematosus patients have unique changes in serum metabolic profiles across age associated with cardiometabolic risk
Study context
- Population
- Female systemic lupus erythematosus (SLE) patients and healthy controls (HCs); age groups ≤ 25 (n = 62/46), 26–49 (n = 50/46), ≥ 50 (n = 52/31)
- Participants
- 164 vs 123
- Exposure
- Female SLE patients vs HCs, across age and by age group
- SLEn = 164
- HCsn = 123reference
- Outcome
- Age-associated changes in serum metabolomic profiles
Methodological detailsserum NMR metabolomics, linear regression across age, age-group comparison by multiple t tests, UK Biobank disease-wide association analysis
- Serum NMR metabolomics
- Linear regression across age
- Age-group comparison by multiple t tests
- UK Biobank disease-wide association analysis
Main finding
As reported in the abstract
Age-specific metabolomic profiles, SLE vs HCs
- Metabolites significantly altered in all SLE age groups, dominated by decreased high-density lipoprotein (HDL) subsets, HDL-bound ApoA1 and increased glycoprotein acetyls (GlycA)
- 25
Observational data: associations, not effects.
Further findings
ApoA1 and GlycA associations
- Differentially associated with disease activity and serological measures, and with atherosclerosis incidence and MI mortality risk by disease-wide association
Glycolysis pathway metabolites (acetone/citrate/creatinine/glycerol/lactate/pyruvate)
- Uniquely increased with age in SLE
- Prednisolone: increased pyruvate/lactate
- HCQ: decreased citrate/creatinine
- Associated with type 1 and type 2 diabetes by disease-wide association
Original publication
Systemic lupus erythematosus patients have unique changes in serum metabolic profiles across age associated with cardiometabolic risk. Rheumatology (Oxford). Published 4 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →