Spondyloarthritis & psoriatic arthritis
Systemic auto-inflammatory manifestations in patients with spondyloarthritis
Authors' conclusion
SpA should be actively investigated in patients with auto-inflammatory manifestations, including undifferentiated auto-inflammatory disease and SD.
Study context
- Population
- Adult and pediatric patients with S-SpA, SD or spondyloarthritis (SpA)
- Participants
- 41 / 39 / 42
- Exposure
- S-SpA vs SpA without auto-inflammatory symptoms, and S-SpA vs Still's disease
- S-SpAn = 41
- SDn = 39
- SpAn = 42reference
- Outcome
- Characterization of S-SpA and comparisons with SpA and SD
Main finding
As reported in the abstract
S-SpA
4.4
median · IQR 7.2 · years
- Latency between systemic and articular manifestations in S-SpA (median, IQR)
- 4.4 (IQR: 7.2) years
- Peripheral arthritis and enthesitis: similar frequency, S-SpA vs SpA
- N.S.
- Tenosynovitis more frequent in S-SpA vs SpA
- P = 0.01
- Uveitis less frequent in S-SpA vs SpA
- P < 0.01
- MRI sacroiliac inflammation and damage equal in S-SpA and SpA
- N.S.
- Fewer corner inflammatory lesions in S-SpA
- P < 0.05
- Less facet joint inflammation in S-SpA
- P < 0.01
- More interspinous enthesitis in S-SpA
- P = 0.01
- More inter-apophyseal capsulitis in S-SpA
- P < 0.01
- Lower-grade fever in S-SpA vs SD
- P < 0.01
- Less rash in S-SpA vs SD
- P < 0.01
- Less weight loss in S-SpA vs SD
- P < 0.05
- More pharyngitis in S-SpA vs SD
- P < 0.01
- More gastrointestinal symptoms in S-SpA vs SD
- P < 0.01
- More chest pain in S-SpA vs SD
- P < 0.05
- ESR, CRP, WBC, ANC, LDH higher in SD
- P < 0.01
- Resolution of systemic symptoms on GC less frequent in S-SpA than SD
- P < 0.01
- Resolution of systemic symptoms on MTX less frequent in S-SpA than SD
- P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) |
|---|---|
| Development of SpA in all SD patients · systemic phaseCoefficient −2.87; CI is for the coefficient | 0.06 (−5.0 to −0.8) |
Original publication
Systemic auto-inflammatory manifestations in patients with spondyloarthritis. Joint Bone Spine. Published 12 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →