Subluxation of the first carpometacarpal joint and age are important factors in reduced hand strength in patients with hand osteoarthritis
Authors' conclusion
Subluxation of CMC1 is associated with reduced grip strength, whereas associations with other radiographic features seem to be confounded by age. In the relationship between age and hand strength, radiographic hand OA severity is not an important mediator.
Study context
- Population
- Patients with hand osteoarthritis (OA) diagnosed by their treating rheumatologist, HOSTAS study
- Participants
- 527 patients
- Outcome
- Determinants of hand strength (pinch and cylinder grip strength)
Methodological detailsregression analysis, mediation analysis
- Regression analysis
- Mediation analysis
Main finding
As reported in the abstract
Pinch grip strength, dominant hand: CMC1 subluxation (adjusted for sex, BMI and age)
CMC1 subluxation, dominant hand, association with pinch grip
−0.511 kg
95% CI −0.975; −0.046
Observational data: associations, not effects.
Further findings
Quality of life
- Reduced hand strength associated with reduced quality of life, less after adjusting for pain
Mediation of age–grip strength association by hand OA
- Low and not significant percentages of mediation
Original publication
Subluxation of the first carpometacarpal joint and age are important factors in reduced hand strength in patients with hand osteoarthritis. Scand J Rheumatol. Published 21 June 2023. doi:10.
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