Subclinical myocardial involvement in a cohort of patients with antisynthetase syndrome
Authors' conclusion
Subclinical myocardial involvement in ASSD is not rare (32%) although its clinical significance is uncertain. Myocardial oedema (T2) was the most frequent finding, followed by increased T1 and/or ECV values likely signalling interstitial fibrosis. Of note, patients in the acute phase showed elevated T2 values.
Study context
- Population
- Patients with antisynthetase syndrome (ASSD) without overt cardiac involvement (56% women; median age 56.3 years)3 in acute phase
- Participants
- 25 patients
- Outcome
- Alterations in multiparametric CMR (subclinical myocardial involvement)
Methodological detailsmultiparametric cardiac magnetic resonance (CMR), native T1 and T2 mapping, extracellular volume (ECV) calculation
- Multiparametric CMR
- Native T1 and T2 mapping
- ECV calculation
Main finding
As reported in the abstract
Pathological findings in CMR
- Pathological CMR findings
- 8 (32%)
- Of these: stable disease / acute phase
- 6 / 2
- Elevated T1 mapping values
- 20% (5/25)
- Elevated T2 mapping values
- 17% (4/25)
- Elevated ECV
- 24% (6/25)
Observational data: associations, not effects.
Further findings
- Acute-phase patients with increased T2 and ECV values
- 2
Original publication
Subclinical myocardial involvement in a cohort of patients with antisynthetase syndrome. Clin Exp Rheumatol. Published 14 March 2024. doi:10.
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