Anti-SAE dermatomyositis: clinical and histologic characteristics from a monocentric Italian cohort
Authors' conclusion
Anti-SAE DM represents a disease subset characterised by classic cutaneous involvement often associated with itching, less severe muscle involvement, but potential pulmonary involvement that should always be investigated in these patients.
Study context
- Population
- Dermatomyositis (DM) patients from a monocentric Italian cohort in the INflammatory MYositis REgistry (INMYRE)92 DM patients screened
- Participants
- 92 patients
- Exposure
- Anti-SAE DM vs anti-Mi2 DM
- Anti-SAEn = 10
- Anti-Mi2n = 17reference
- Outcome
- Clinical (skin, muscle, extra-muscular) and histological characteristics
Methodological detailsmonocentric, registry-based (INMYRE)
- Monocentric
- Registry-based (INMYRE)
Main finding
As reported in the abstract
Clinical and histological characteristics
- Skin itching: anti-SAE 60% vs anti-Mi2 11.8%, p<0.01
- 60% vs. 11.8%
- Shawl sign: anti-SAE 40% vs anti-Mi2 5.9%, p<0.05
- 40% vs. 5.9%
- Lung involvement: anti-SAE 30% vs anti-Mi2 0%, p<0.05
- 30% vs. 0%
- Creatine kinase, median [IQR]: anti-SAE 101 [58-647] vs anti-Mi2 1984 [974-3717], p<0.05
- 101 [58-647] vs. 1984 [974-3717]
- Muscle fibre degeneration and necrosis: anti-SAE 1.5%±1.7 vs anti-Mi2 5.9%±3.2, p<0.05
- 1.5%±1.7 vs. 5.9%±3.2
Observational data: associations, not effects.
Further findings
Prevalence among DM patients
Original publication
Anti-SAE dermatomyositis: clinical and histologic characteristics from a monocentric Italian cohort. Clin Exp Rheumatol. Published 14 March 2024. doi:10.
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