Vasculitis & polymyalgia rheumatica
Stroke characteristics in giant cell arteritis and Takayasu arteritis: A multicenter retrospective cohort study of 108 patients
Authors' conclusion
Stroke presentation differs between GCA and TAK, with predominant vertebrobasilar involvement in GCA. Carotid involvement is more frequent in TAK and often requires vascular procedures.
Study context
- Population
- Patients with giant cell arteritis (GCA) or TAK (ACR/EULAR 2022 criteria) and ≥1 imaging-confirmed stroke; excluded TIA, strokes after age fifty in TAK, or strokes secondary to AF108 analysed
- Participants
- 108 patients
- Exposure
- GCA vs TAK
- GCAn = 68
- TAKn = 40reference
- Outcome
- Epidemiological, clinical and prognostic features of stroke
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Stroke territory
Vertebrobasilar territory
Carotid territory
- GCA vs TAK: P < 0.001
- GCA vs TAK: P < 0.001
Observational data: associations, not effects.
Further findings
Age at stroke
P < 0.001
Hypertension
P = 0.003
Dyslipidemia
P = 0.002
Cerebellar syndrome
P = 0.001
Cranial nerve involvement
P = 0.017
Sensory deficits
P < 0.001
Vascular intervention required
P < 0.001
| Outcome | GCA | TAK | P value |
|---|---|---|---|
| Female-to-male ratio | 0.78 | 5.2 | P < 0.001 |
Original publication
Stroke characteristics in giant cell arteritis and Takayasu arteritis: A multicenter retrospective cohort study of 108 patients. Semin Arthritis Rheum. Published 8 February 2026. doi:10.
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