Vasculitis & polymyalgia rheumatica
Proteomic Profiling of the Large‐Vessel Vasculitis Spectrum Identifying Shared Signatures of Innate Immune Activation and Stromal Remodeling
Authors' conclusion
These findings suggest shared pathobiology across the LVV spectrum involving innate immunity, lymphocyte homeostasis, and tissue remodeling.
Study context
- Population
- Patients with large-vessel vasculitis (LVV) (TAK, large-vessel GCA (LV-GCA)) and HCs; patients presenting acutely with possible cranial giant cell arteritis (GCA)two cohorts
- Participants
- 96 / 35 / 35 / 150 / 89
- Comparison
- TAK, LV-GCA and HCs; confirmed vs excluded cranial GCA (C-GCA)
- TAKn = 96
- LV-GCAn = 35
- HCsn = 35reference
- C-GCAn = 150
- Not C-GCAn = 89reference
- Outcome
- Differentially abundant plasma proteins (DAPs)
Methodological detailsplasma proteomic profiling of 184 proteins, two cohorts, comparison with published arterial transcriptomic data
- Plasma proteomic profiling of 184 proteins
- Two cohorts
- Comparison with published arterial transcriptomic data
Main finding
As reported in the abstract
- Differentially abundant proteins (DAPs) in TAK vs HCs (cohort 1)
- 52
- DAPs in LV-GCA vs HCs (cohort 1)
- 72
- Disease activity-associated proteins within TAK
- 16
- Disease activity-associated proteins within LV-GCA
- 18
- DAPs in C-GCA vs Not C-GCA (cohort 2)
- 31
- Shared DAPs across TAK, LV-GCA and biopsy-proven C-GCA (incl. IL-6, CCL7, CSF1, TIMP1, TNC, TNFSF14, IL-7R)
- 26
- DAPs whose corresponding gene was differentially expressed in arterial tissue
- 42%
Original publication
Proteomic Profiling of the Large‐Vessel Vasculitis Spectrum Identifying Shared Signatures of Innate Immune Activation and Stromal Remodeling. Arthritis Rheumatol. Published 27 February 2025. doi:10.
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