Vasculitis & polymyalgia rheumatica
Prevalence and clinical significance of anti-neutrophil cytoplasmic antibodies in interstitial lung disease: a retrospective cohort study
Authors' conclusion
The prevalence of ANCAs in patients with ILD is not rare, and ANCA testing in ILD patients is necessary. Oddly shaped cysts with or without a UIP pattern may be a characteristic chest imaging manifestation of ANCA-positive ILDs.
Study context
- Population
- Chinese patients with interstitial lung disease (ILD) (including idiopathic pulmonary fibrosis) with available ANCA results, First Affiliated Hospital of Ningbo University, March 2010 to October 2023
- Participants
- 706 patients
- Exposure
- ANCA-positive ILD vs ANCA-negative ILD
- ANCA-POSITIVE ILDn = 158
- Outcome
- Prevalence of ANCAs in ILD
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
ANCA positivity in ILD
ANCA-POSITIVE ILD
22.4%
158
Observational data: associations, not effects.
Further findings
All-cause mortality
P = 0.033
| Outcome | ANCA-POSITIVE ILD | ANCA-NEGATIVE ILD |
|---|---|---|
| ANCA positivity after ILD diagnosis · on average (41.6 ± 31.4) months after ILD diagnosis | 58.2% | — not stated in the abstract |
— not stated in the abstract
- Honeycombing on chest CT · significantly greater in ANCA-positive ILD
- P < 0.001
- Oddly shaped cysts on chest CT · significantly greater in ANCA-positive ILD
- P < 0.001
Clinical features, ANCA-positive vs ANCA-negative ILD
- ANCA-positive ILD patients tended to be older, had higher CRP and ESR levels, and a significantly greater proportion of RF positivity
Usual interstitial pneumonia (UIP) pattern (most common chest HRCT pattern)
- UIP pattern
- 56.3%
Survival in ANCA-positive ILD (independent factors)
- Acute exacerbation of ILD, shorter survival: HR
- 2.40 (95% CI 1.37-4.22, P = 0.002)
- GC combined with immunosuppressants, longer survival: HR
- 0.30 (95% CI 0.16-0.57, P < 0.001)
Original publication
Prevalence and clinical significance of anti-neutrophil cytoplasmic antibodies in interstitial lung disease: a retrospective cohort study. Rheumatology (Oxford). Published 25 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →