Vasculitis & polymyalgia rheumatica
Pulmonary nontuberculous mycobacteria disease and anti-neutrophil cytoplasmic antibody positivity: a retrospective analysis of long-term clinical outcomes including vasculitis onset
Authors' conclusion
Our findings suggest an association between NTM infection and AAV and highlight the importance of measuring ANCA in patients with NTM.
Study context
- Population
- Patients with pulmonary nontuberculous mycobacterial (NTM) disease who subsequently underwent myeloperoxidase (MPO)- or PR3-ANCA testing
- Participants
- 63 patients
- Outcome
- ANCA positivity rate and incidence of AAV in pulmonary NTM disease
Methodological detailsliterature review of previously reported cases
- Literature review of previously reported cases
Main finding
As reported in the abstract
ANCA positivity
Anti-neutrophil cytoplasmic antibody (ANCA) positive (predominantly MPO-ANCA)
7
11.1%
Observational data: associations, not effects.
Further findings
ANCA-associated vasculitis (AAV) among ANCA-positive patients
- Developed AAV
- 5 (71.4%)
- Concurrent NTM culture positivity at AAV diagnosis
- 3
- MPA
- 3
- GPA
- 1
- EGPA
- 1
- Most patients developed glomerulonephritis
Literature review: previously reported AAV cases associated with pulmonary NTM disease
- Previously reported cases
- 8
Original publication
Pulmonary nontuberculous mycobacteria disease and anti-neutrophil cytoplasmic antibody positivity: a retrospective analysis of long-term clinical outcomes including vasculitis onset. Clin Exp Rheumatol. Published 29 March 2025. doi:10.
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