Systemic sclerosis & Raynaud's
Stratification according to autoantibody status in systemic sclerosis reveals distinct molecular signatures
Authors' conclusion
Patients with SSc display varying biological profiles based on their serological status.
Study context
- Population
- Patients with systemic sclerosis (SSc) enrolled in the PRECISESADS cross-sectional study
- Participants
- 206 patients
- Exposure
- SSc patients stratified by ACA and anti-SCL70 antibody status
- Outcome
- Clinical and molecular signatures by serological status
Methodological detailsomics analyses (transcriptomic, flow cytometric, cytokine, metabolomic)
- Omics analyses (transcriptomic, flow cytometric, cytokine, metabolomic)
Main finding
As reported in the abstract
- SCL70: severe clinical features (diffuse cutaneous sclerosis, pulmonary fibrosis) and unique transcriptomic profiles
- SCL70: pro-inflammatory and fibrotic signature with impaired tissue remodelling and increased carnitine metabolism
- ACA: immunomodulation and tissue homeostasis signature and increased phospholipid metabolism
Observational data: associations, not effects.
Original publication
Stratification according to autoantibody status in systemic sclerosis reveals distinct molecular signatures. Ann Rheum Dis. Published 22 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →