Systemic sclerosis & Raynaud's
Racial variability in immune responses only partially explains differential systemic sclerosis disease severity
Authors' conclusion
Black and white individuals with SSc have distinct autoantibody profiles. Autoantibodies explain only a fraction of the effect of race on clinical outcomes, suggesting other factors contribute to disparate outcomes between these groups.
Study context
- Population
- Systemic sclerosis (SSc) patients, geographically diverse, with systematic autoantibody testing (Euroimmun panel and ELISA for U1RNP)
- Participants
- 803 vs 2,178
- Exposure
- Self-identified black vs white SSc patients
- Blackn = 803
- Whiten = 2,178reference
- Outcome
- Autoantibody distribution and associated phenotype by self-identified race; mediation of race effect on outcomes by autoantibodies
Methodological detailslogistic regression, mediation analysis comparing race coefficients with and without autoantibodies
- Logistic regression
- Mediation analysis comparing race coefficients with and without autoantibodies
Main finding
As reported in the abstract
Adjusting for autoantibodies decreased race effect on telangiectasias, FVC <70%, pulmonary hypertension and severe lung, heart, muscle and gastrointestinal disease
11%-44%
Adjusting for autoantibodies increased race association with renal crisis and severe kidney disease
37%-52%
Observational data: associations, not effects.
Original publication
Racial variability in immune responses only partially explains differential systemic sclerosis disease severity. Ann Rheum Dis. Published 21 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →