Systemic sclerosis & Raynaud's
Step forward in early recognition of systemic sclerosis: data from the Leiden Combined Care in Systemic Sclerosis (CCISS) cohort
Authors' conclusion
We observed a decrease in disease duration in Leiden CCISS cohort at cohort entry, possibly indicating more timely diagnosis of SSc.
Study context
- Population
- Dutch systemic sclerosis (SSc) patients fulfilling ACR/EULAR 2013 SSc criteria, Leiden CCISS cohort
- Participants
- 643 patients
- Exposure
- Cohort-entry periods 2010-2013 vs 2014-2017 vs 2018-2021
- 2010-2013n = 229reference
- 2014-2017n = 207
- 2018-2021n = 207
- Outcome
- Duration between onset of disease symptoms and cohort entry (early recognition of SSc) over time
Methodological detailssingle-centre cohort, stratified by sex and autoantibodies
- Single-centre cohort
- Stratified by sex and autoantibodies
Main finding
As reported in the abstract
Duration between symptom onset and cohort entry
- Decreased over time in males and females, but always longer in females than in males
Observational data: associations, not effects.
Further findings
| Outcome | 2010-2013 | 2018-2021 |
|---|---|---|
| ILD at presentation in ATA+ patients | 25% | 19% |
Digital ulcers (DU) at presentation
- Proportion decreased, especially in ACA+ SSc
Interstitial lung disease (ILD) at presentation in ATA+ patients
- Almost no ACA+ patients presented with ILD
Clinically meaningful ILD and diffuse cutaneous SSc (dcSSc) at presentation
- Reduction observed
Overall 8-year survival by sex
- Males
- 59% (95% CI 40% to 73%)
- Females
- 89% (95% CI 82% to 93%)
- Trend for improvement over time; always worse in males
Original publication
Step forward in early recognition of systemic sclerosis: data from the Leiden CCISS cohort. RMD Open. Published 7 April 2023. doi:10.
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