Systemic sclerosis & Raynaud's
Anti-carbamylated protein antibodies in systemic sclerosis
Authors' conclusion
We do not observe a relevant clinical association between anti-CarP antibody response and skin involvement in SSc.
Study context
- Population
- Systemic sclerosis (SSc) patients from the Leiden CCISS cohort (mean age 55 years; 80% female)
- Participants
- 194 / 83 / 24 / 98
- Exposure
- SSc patients vs other connective tissue diseases/RP, RA patients and healthy controls
- SScn = 194
- Other connective tissue diseases/Raynaud's Phenomenonn = 83
- Rheumatoid arthritisn = 24
- Healthy controlsn = 98reference
- Outcome
- Presence of anti-CarP IgG, IgA and IgM isotypes and association with skin involvement (mRSS)
Methodological detailsage and sex-matched healthy controls, ELISA
- Age and sex-matched healthy controls
- ELISA
Main finding
As reported in the abstract
Prevalence of anti-CarP IgG
P = 0.007
Observational data: associations, not effects.
Further findings
| Outcome | SSc | P value |
|---|---|---|
| Prevalence of anti-CarP IgA and IgM and levels of anti-CarP isotypes, SSc vs healthy controls | 8% | |
| anti-CarP IgA positive | 16 (8%) | |
| anti-CarP IgM positive | 36 (19%) | |
| Anti-CarP IgA levels, ATA vs ACA positive SScHigher in ATA | P = 0.015 |
- Anti-CarP IgA levels, anti-topoisomerase antibodies (ATA) vs anti-centromere antibodies (ACA) positive SSc: ATA 616 (interval 359–1103) aU/ml
- Anti-CarP IgA levels, ATA vs ACA positive SSc: ACA 424 (interval 300–673) aU/ml
Prevalence of anti-CarP IgA and IgM and levels of anti-CarP isotypes, SSc vs healthy controls
- Comparable between SSc patients and healthy controls
Correlation of anti-CarP IgG levels with modified Rodnan Skin Score (mRSS) in SSc
- No correlation between anti-CarP IgG levels and mRSS (r)
- r = 0.141, p = 0.049
- No correlation for anti-CarP IgM and IgA levels with mRSS
Correlation between age and anti-CarP isotype levels
- No significant correlations
Original publication
Anti-carbamylated protein antibodies in systemic sclerosis. Arthritis Res Ther. Published 21 July 2023. doi:10.
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