Lupus & antiphospholipid syndrome
Status of TWEAK DNA methylation and mRNA expression in systemic lupus erythematosus
Authors' conclusion
This study suggests that TWEAK DNA methylation is a valuable as a focus for epigenetic studies because of it potentially influencing TWEAK gene expression in SLE patients.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and sex-age matched healthy controls
- Participants
- 178 vs 131
- Comparison
- SLE vs healthy controls
- SLEn = 178
- HCn = 131reference
- Outcome
- Serum TWEAK, TWEAK mRNA expression and TWEAK promoter DNA methylation
Methodological detailssex-age matched healthy controls
- Sex-age matched healthy controls
Main finding
As reported in the abstract
- Serum TWEAK concentrations not significantly different between SLE and HCs
- TWEAK mRNA expression significantly lower in SLE vs HC
- Global DNA methylation of TWEAK significantly higher in SLE vs HC
- TWEAK methylation negatively correlated with TWEAK mRNA expression
Observational data: associations, not effects.
Further findings
Serum TWEAK by renal involvement and disease activity (SLE subgroups)
- Significantly lower serum TWEAK with renal involvement vs without
- Serum TWEAK reduced in clinically active (SLEDAI ≥ 10) vs stable (SLEDAI < 10) patients
- Serum TWEAK significantly associated with SLEDAI
TWEAK methylation by renal involvement and disease activity (SLE subgroups)
- Higher TWEAK global methylation and variation in certain CpG island methylation with renal involvement and in clinically active patients
Original publication
Status of TWEAK DNA methylation and mRNA expression in systemic lupus erythematosus. Lupus. Published 23 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →