Lupus & antiphospholipid syndrome
Vitamin D receptor expression level in patients with SLE and its relationship with vitamin D status, disease course and bone mineral density
Authors' conclusion
Low VDR concentration is a common phenomenon in patients with SLE associated with age, high disease activity, vitamin D supply and serum CTX concentration.
Study context
- Population
- Patients with SLE and controls
- Participants
- 99 vs 30
- Exposure
- SLE vs controls
- SLEn = 99
- Controlsn = 30reference
- Outcome
- Serum VDR concentration and its relationship with vitamin D status, disease course, bone turnover markers and BMD
Main finding
As reported in the abstract
Serum VDR level
P < 0.01
- SLE patients with low vitamin D receptor (VDR) concentrations
- 77.8%
- SLE patients with relatively normal or high VDR levels
- 22.2%
Observational data: associations, not effects.
Further findings
Correlates of VDR level in SLE
- Low VDR vs age (p=0.054)
- r=−0.22
- VDR vs C-reactive protein (CRP)
- r=−0.22
- VDR vs IL-6
- r=−0.21
- VDR vs SLEDAI-2K
- r=−0.20
- CTX increase with VDR decrease (p<0.05)
- r=−0.27
- Vitamin D 33.55% lower in low VDR vs relatively normal VDR (p=0.0001)
- r=0.47
- No relationship with sex, disease duration, body mass index (BMI), cumulative glucocorticoid (GC) dose, LN, creatinine, GFR
- No significant difference in Z-score, T-score and bone mineral density (BMD) between low and relatively normal VDR (p>0.05)
Original publication
Vitamin D receptor expression level in patients with SLE and its relationship with vitamin D status, disease course and bone mineral density. Lupus Sci Med. Published 16 September 2025. doi:10.
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