Skin microcirculation dynamics are impaired in patients with rheumatoid arthritis and no cardiovascular comorbidities
Authors' conclusion
Patients with RA present impaired microvascular reactivity regardless of CVD risk factors at a preclinical stage preceding CVD.
Study context
- Population
- Rheumatoid arthritis (RA) patients and non-RA individuals without cardiovascular comorbidities
- Participants
- 35 vs 35
- Comparison
- RA patients vs non-RA individuals, all without cardiovascular comorbidities
- RAn = 35
- Controlsn = 35reference
- Outcome
- Skin microvascular reactivity (laser speckle contrast imaging with post-occlusive reactive hyperaemia)
Main finding
As reported in the abstract
- Significantly impaired in RA vs controls
- Presence of RA independently predicted altered microvascular reactivity in multivariate analysis
Observational data: associations, not effects.
Further findings
Correlation of skin microcirculation dynamics with coronary microvascular perfusion, peripheral arterial stiffness and carotid atherosclerosis
- Significantly correlated with coronary microvascular perfusion and peripheral arterial stiffness, not carotid atherosclerosis, even after adjustment for cardiovascular disease (CVD) risk factors
Original publication
Skin microcirculation dynamics are impaired in patients with rheumatoid arthritis and no cardiovascular comorbidities. Clin Exp Rheumatol. Published 29 September 2022. doi:10.
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