Lupus & antiphospholipid syndrome
Significant glomerular immunoglobulin M (IgM) deposition predicts poorer kidney outcomes in lupus nephritis compared with other forms of immune complex deposits
Main finding · Renal progression (doubling of serum creatinine or ESRD)Result — go to the resultAdjusted hazard ratio 1.485 95% CI 1.040–2.119Authors' conclusion
High glomerular IgM deposition emerged as an independent prognostic marker for adverse renal outcomes in LN, potentially outperforming other individual immune complexes.
Study context
- Population
- Biopsy-proven Lupus Nephritis (LN) patients (1996–2019), First Affiliated Hospital of Sun Yat-sen University
- Participants
- 952 patients
- Exposure
- High vs low glomerular IgM deposition
- Outcome
- Composite of:
- Doubling of serum creatinine from baseline
- Development of end-stage renal disease (ESRD)
Methodological detailssingle-centre, multivariable Cox regression
- Single-centre
- Multivariable Cox regression
Main finding
As reported in the abstract
Renal progression (doubling of serum creatinine or ESRD)
Adjusted hazard ratio
1.485
95% CI 1.040–2.119
P = 0.029
High IgMvs Low IgM
aHR 1.485 (95% CI 1.040–2.119); P = 0.029
- Only high glomerular IgM deposition, among the immune complexes studied, significantly associated with adverse renal outcomes
- P = 0.025
Observational data: associations, not effects.
Secondary outcomes
| Outcome | High IgM | Low IgM | P value |
|---|---|---|---|
| Baseline SLEDAI | 16 (range 12–20) | 15 (range 12–18) | P < 0.001 |
Serum complement levels
- Lower median serum C3 and C4 levels with high IgM, both p<0.05
Correlation of high glomerular IgM with other deposits
- Correlation with high immunoglobulin A (IgA) deposition (r)
- 0.48
- Correlation with C3 deposition (r)
- 0.40
- Both p<0.01
Original publication
Significant glomerular IgM deposition predicts poorer kidney outcomes in lupus nephritis compared with other forms of immune complex deposits. Lupus Sci Med. Published 10 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →