Signals for mineralization and inflammation are observed following treatment with fasinumab, a specific nerve growth factor inhibitor
Authors' conclusion
In this post hoc analysis, signals for bone turnover/mineralization, and inflammation increased following treatment with fasinumab. Increases were generally dose-dependent, reversible, and more pronounced in patients with arthropathy than those without.
Study context
- Population
- Patients with OA of the knee or hip in phase 2 and 3 clinical studies of fasinumab
- Participants
- 5,772 patients
- Comparison
- Fasinumab-treated OA patients with arthropathies vs without arthropathies
Primary result
As reported in the abstract
Arthropathy vs No arthropathyDifference, U/L (95% CI)
Alkaline phosphatase, 6 mg every 8 weeks, Week 16
10.36(0.06–20.66)
Arthropathy vs No arthropathyDifference, mg/L (95% CI)
CRP, 6 mg every 8 weeks, Week 16
3.09(0.07–6.12)
Original publication
Signals for mineralization and inflammation are observed following treatment with fasinumab, a specific nerve growth factor inhibitor. Osteoarthritis Cartilage. Published 11 July 2026. doi:10.
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