Short- and Long-Term Mortality of Hospitalized Patients With Autoimmune Rheumatic Diseases and Serious Infections: A National Cohort Study
Authors' conclusion
Among patients hospitalized for an infection, the risk of in-hospital and 3-year mortality was not increased among those with ARD compared to those without ARD.
Study context
- Population
- Members of the largest health maintenance organization in Israel, aged > 18 years, hospitalized for the first time with a serious infection, 2003–2019first admission with serious infection
- Participants
- 365,247 members
- Exposure
- Patients with autoimmune rheumatic diseases (ARD) vs matched patients without ARD
- Rheumatoid arthritis (RA)n = 9,755
- SLEn = 1,351
- Spondyloarthritis (SpA)n = 2,120
- SScn = 584
- Vasculitisn = 3,214
- Outcome
- In-hospital mortality and 3-year mortality (landmark analysis among survivors of the index hospitalization)
Methodological detailsnational cohort, matched 1:3 by age, sex and ethnicity, 3-year landmark analysis, multivariate analysis
- National cohort
- Matched 1:3 by age, sex and ethnicity
- 3-year landmark analysis
- Multivariate analysis
Main finding
As reported in the abstract
In-hospital mortality (matched multivariate analysis)
Each group vs without ARDOdds ratio (95% CI)
RA
0.89(0.81–0.97)
SpA
0.77(0.63–0.94)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| 3-year mortality (landmark analysis, matched) · 3 yearsRAvs Without ARDMatched analysis | 0.82 (0.78–0.86) | |
| 3-year mortality (landmark analysis, matched) · 3 yearsVasculitisvs Without ARDMatched analysis | 0.86 (0.80–0.93) | |
| 0.512Hazard ratio (log scale) |
Original publication
Short- and Long-Term Mortality of Hospitalized Patients With Autoimmune Rheumatic Diseases and Serious Infections: A National Cohort Study. J Rheumatol. Published 1 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →