Development and validation of a risk score for serious infection in patients with rheumatic diseases receiving prolonged high-dose glucocorticoids
Performance · Serious infectionResult — go to the resultHazard ratio 4.85 CI 3.53–6.67Authors' conclusion
In patients with AIRDs receiving prolonged high-dose glucocorticoids, the CORAL score successfully identified those at high risk of serious infection.
Study context
- Population
- Patients with autoimmune inflammatory rheumatic diseases (AIRDs) treated with prolonged (≥ 4 weeks) high-dose glucocorticoids (GCs) (≥ 30 mg/day prednisone), two referral hospitalsderivation cohort
- Participants
- 1,635 patients
- Comparison
- High-risk vs low-risk
- High-riskn = 343
- Outcome
- Incidence of serious infection
- Follow-up
- 1 year
Methodological detailstwo referral hospitals, Cox regression with LASSO regularization, external validation cohort
- Two referral hospitals
- Cox regression with LASSO regularization
- External validation cohort
Performance
Serious infection
Hazard ratio
4.85
CI 3.53–6.67
High-riskvs Low-risk
HR 4.85 (CI 3.53–6.67)
As reported in the abstract
- Serious infection in derivation cohort, patients
- 153
- Incidence rate per 100 person-years
- 10.5 (95% CI 9.0-12.3)
- CORAL score (0-20) AUROC
- 0.726 (95% CI 0.681-0.771)
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| All-cause mortality | 4.55 (2.91–7.11) | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Development and validation of a risk score for serious infection in patients with rheumatic diseases receiving prolonged high-dose glucocorticoids. Arthritis Res Ther. Published 5 March 2026. doi:10.
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