Across rheumatic diseases

A scoping review to identify clinician reported measurement instruments of glucocorticoid toxicity for the OMERACT Glucocorticoid Impact working group

Semin Arthritis RheumPublished Scoping review

Authors' conclusion

31 candidate ClinROs were identified for measurement of physiological and psychosocial impact domains of GC impact.

Study context

Population
Studies of patients with inflammatory conditions treated with exogenous glucocorticoids (GCs) reporting a clinician or patient reported outcome measurestudies with ClinROs
Participants
57 studies
Outcome
Clinician reported outcome measures (ClinROs) of GC-related adverse effects (AEs), by OMERACT GC domain
Methodological detailshand search of abstracts at major rheumatology meetings, Medline, EMBASE, CINHAL and CENTRAL searched from inception to August 2024; meeting abstracts August 2019 to August 2024
  • Hand search of abstracts at major rheumatology meetings
  • Medline, EMBASE, CINHAL and CENTRAL searched from inception to August 2024; meeting abstracts August 2019 to August 2024

Main finding

As reported in the abstract

Candidate ClinROs of GC impact
Individual or grouped candidate ClinROs identified
31
Studies in an AIRD population
20 (35.1%)
GCs delivered systemically
48/57, 84.2%
Bone fragility assessed (studies)
31
Mood disturbance assessed (studies)
20
Fatigue assessed (studies)
0
Sleep disturbance assessed (studies)
2
Appearance assessed (studies)
1

Original publication

A scoping review to identify clinician reported measurement instruments of glucocorticoid toxicity for the OMERACT Glucocorticoid Impact working group. Semin Arthritis Rheum. Published 19 August 2026. doi:10.1016/j.semarthrit.2026.153056

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