Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis
Authors' conclusion
The combination of proteomics and transcript expression by multi-enrichment analysis broadened the identification of up- and down-regulated pathways among active DM and juvenile DM patients.
Study context
- Population
- Active adult dermatomyositis (DM) and JDM patients receiving immunosuppressive therapies; peripheral blood
- Comparison
- Adult DM and JDM patients vs matched healthy controls
- DMn = 14
- Juvenile DMn = 12
- Outcome
- Transcript and protein expression: gene locus and pathway regulation in peripheral blood
Methodological detailsmatched healthy controls, multi-enrichment analysis
- Matched healthy controls
- Multi-enrichment analysis
Main finding
As reported in the abstract
Gene loci significantly altered at transcript or protein level across DM or JDM
1,124
Genes shared between DM and JDM
70
Original publication
Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis. Arthritis Rheumatol. Published 13 August 2023. doi:10.
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