Monoarticular juvenile idiopathic arthritis as a distinct clinical entity A proof-of-concept study
Authors' conclusion
MonoJIA, defined as persistent arthritis of unknown origin of a single joint for at least three years, seems to be a separate clinical entity from oligoJIA.
Study context
- Population
- Patients with oligoJIA and at least two years follow-upmean follow-up 11.4 years
- Participants
- 347 patients
- Exposure
- Persistent monoarticular JIA vs oligoarticular JIA
- Monoarticular Juvenile Idiopathic Arthritis (monoJIA)n = 118
- oligoJIAn = 229reference
- Outcome
- Clinical characteristics, monoJIA vs oligoJIA
Methodological detailsproof-of-concept, comparative, Patients without clinical follow-up for >12 months contacted by structured telephone interview
- Proof-of-concept
- Comparative
- Patients without clinical follow-up for >12 months contacted by structured telephone interview
Main finding
As reported in the abstract
- Age at onset (years), monoJIA vs oligoJIA (later in monoJIA)
- 6.1 vs. 4.7
- Female prevalence, monoJIA vs oligoJIA (lower in monoJIA)
- 70.3 vs. 83.4%
- Benign joint hypermobility, monoJIA vs oligoJIA (higher in monoJIA)
- 61.9 vs. 46.3%
- Uveitis, monoJIA vs oligoJIA (lower in monoJIA)
- 14.4 vs. 34.1%
- ANA+, monoJIA vs oligoJIA (lower in monoJIA)
- 68.6 vs. 89.5%
Observational data: associations, not effects.
Further findings
Switch from monoarticular onset to oligoarticular course · by the first three years from onset
- Patients switching
- 78 patients (38.8%)
- 196 with monoarticular onset
Original publication
Monoarticular juvenile idiopathic arthritis as a distinct clinical entity A proof-of-concept study. Pediatr Rheumatol Online J. Published 10 August 2023. doi:10.
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