Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis
Authors' conclusion
Coordinate analysis of protein expression in DM and JDM patient sera by a multiplex immunoassay validated previous gene expression studies and identified novel dysregulated proteins, altered signaling pathways, and candidate disease activity biomarkers.
Study context
- Population
- Active adult DM and JDM patients and matched healthy controls
- Comparison
- Active adult DM and JDM patients vs matched healthy controls
- DMn = 17
- JDMn = 17
- Outcome
- Differentially regulated serum proteins, altered pathways and candidate disease activity biomarkers
Methodological detailscase–control, multiplex immunoassay, matched healthy controls
- Case–control
- Multiplex immunoassay
- Matched healthy controls
Main finding
As reported in the abstract
Differentially expressed serum proteins vs healthy controls
- Proteins differentially expressed in DM and JDM sera (of 172)
- 78
- Proteins differentially expressed in DM
- 48
- Proteins differentially expressed in JDM
- 32
- Proteins differentially expressed in both DM and JDM
- 14
- Additional differentially expressed proteins after combining DM and JDM cohorts
- 12
Further findings
Proteins correlating with global, muscle and/or skin disease activity
- Proteins correlating in DM
- 22
- Proteins correlating in JDM
- 24
- Proteins correlating in both DM and JDM
- 7
- IL1RL1 candidate global disease activity biomarker in DM and JDM
Original publication
Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis. Arthritis Res Ther. Published 11 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →