Systemic sclerosis & Raynaud's
Sex-specific difference in cardiac function in patients with systemic sclerosis: association with cardiovascular outcomes
Authors' conclusion
In patients with SSc, male sex is associated with worse cardiovascular outcomes even after adjusting for important clinical characteristics. LV GLS was more impaired in men as compared with women and potentially explains the sex difference in cardiovascular outcomes.
Study context
- Population
- Patients with systemic sclerosis (SSc) from four centres evaluated with standard and advanced echocardiography
- Participants
- 746 patients4 centres
- Exposure
- Men vs women with SSc
- Menn = 118
- Womenn = 628reference
- Outcome
- Combined endpoint of cardiovascular events-hospitalisation/death
Methodological detailsmulticentre (four centres)
- Multicentre (four centres)
Main finding
As reported in the abstract
Cardiovascular events-hospitalisation/mortality (combined endpoint) · median follow-up 48 months (IQR: 26-80)
- Combined endpoint occurred in 182 patients
- Sex differences maintained after adjusting for clinical confounders, but neutralised when matching for LV GLS
- Men vs Women: Log-rank=0.003
Observational data: associations, not effects.
Further findings
| Outcome | Men | Women | P value |
|---|---|---|---|
| LV GLS, adjusted for clinical characteristicsMore impaired LV GLS in men | −19% (IQR −20%–-17%) | −21% (IQR −22%–-19%) | P < 0.001 |
LV ejection fraction and diastolic function, adjusted
- Not significantly different anymore after adjustment
Original publication
Sex-specific difference in cardiac function in patients with systemic sclerosis: association with cardiovascular outcomes. RMD Open. Published 10 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →