Sex-Related Differences in Dispensation of Rheumatic Medications in Older Patients With Inflammatory Arthritis: A Population-Based Study
Authors' conclusion
This study did not identify any sex difference in the use of DMARDs among older patients with RA and PsA.
Study context
- Population
- Patients with incident rheumatoid arthritis (RA) and psoriatic arthritis (PsA) aged ≥ 66 years at diagnosis, Ontario, Canada (2010–2017)13,613 RA (64% female)
- Exposure
- Older female vs male patients with early RA and PsA
- Outcome
- Yearly dispensation of rheumatic drugs (csDMARDs, advanced therapy, nonsteroidal antiinflammatory drugs (NSAIDs), opioids, oral corticosteroids)
- Follow-up
- 3 years after diagnosis
Methodological detailspopulation-based, health administrative data, multivariable regression adjusted for confounders
- Population-based
- Health administrative data
- Multivariable regression adjusted for confounders
Main finding
As reported in the abstract
Dispensation of disease-modifying antirheumatic drugs (DMARDs)
- No sex difference in DMARD dispensation in either RA or PsA
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Opioid dispensation, RAFemalevs MaleRange across years: lowest of OR 1.39 to OR 1.51 | 1.39 (1.22–1.58) | |
| Opioid dispensation, RAFemalevs MaleRange across years: highest of OR 1.39 to OR 1.51 | 1.51 (1.32–1.72) | |
| NSAID dispensation, RAFemalevs MaleRange across years: lowest of OR 1.14 to OR 1.16 | 1.14 (1.04–1.25) | |
| NSAID dispensation, RAFemalevs MaleRange across years: highest of OR 1.14 to OR 1.16 | 1.16 (1.04–1.30) | |
| 0.512Odds ratio (log scale) |
Patient–physician sex concordance (subgroup)
- More intense use of advanced therapy in RA and of csDMARDs in PsA when patient and physician sex concordant
Original publication
Sex-Related Differences in Dispensation of Rheumatic Medications in Older Patients With Inflammatory Arthritis: A Population-Based Study. J Rheumatol. Published 1 May 2024. doi:10.
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