Circulating Interleukin 17A and Other Inflammatory Proteins May Predict Cardiovascular Disease in Early Rheumatoid Arthritis
Authors' conclusion
Circulating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude the possibility that this finding is due to multiple testing.
Study context
- Population
- Consecutive patients with early rheumatoid arthritis (RA) recruited 1995–2002data on baseline proteins and cardiovascular disease (CVD)
- Participants
- 163 patients
- Outcome
- CVD (and CAD) by baseline levels of 92 inflammatory proteins
Methodological detailsconsecutive patients, Cox regression, hypothesis-driven and exploratory analyses, principal component analysis
- Consecutive patients
- Cox regression
- Hypothesis-driven and exploratory analyses
- Principal component analysis
Main finding
As reported in the abstract
CVD per IL-17A level
IL-17A associated with CVD, HR (adjusted for age, sex, hypertension, diabetes, smoking and ESR)
1.35
95% CI 1.02–1.78
Observational data: associations, not effects.
Further findings
CAD per IL-17A level
- Not significantly associated with CAD
Osteoprotegerin (OPG) and CVD/CAD
- Significantly associated with both outcomes, but only in crude models
IL-6, TNF, MCP-1, IL-8 and CVD/CAD
- No associations observed
MCP-3 and CVD/CAD (exploratory)
- Significant associations with both outcomes in crude models
- Exploratory analysis
Original publication
Circulating Interleukin 17A and Other Inflammatory Proteins May Predict Cardiovascular Disease in Early Rheumatoid Arthritis. J Rheumatol. Published 1 May 2024. doi:10.
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