Spondyloarthritis & psoriatic arthritis
Sex differences in serum proteomic profiles in psoriatic arthritis
Authors' conclusion
Significantly more dysregulated proteins and biological pathways were found in males than in females with PsA.
Study context
- Population
- Patients with active PsA and age- and sex-matched non-psoriatic controls
- Participants
- 50 / 50 / 50
- Exposure
- Male and female PsA patients vs age- and sex-matched non-psoriatic controls
- PsA malesn = 50
- PsA femalesn = 50
- Controlsn = 50reference
- Outcome
- Sex-specific differentially expressed serum proteins (DEPs) and enriched pathways
Methodological detailsuntargeted proteomic study, aptamer-based panel of 6402 serum proteins, age- and sex-matched non-psoriatic controls, machine learning classifiers (random forest)
- Untargeted proteomic study
- Aptamer-based panel of 6402 serum proteins
- Age- and sex-matched non-psoriatic controls
- Machine learning classifiers (random forest)
Main finding
As reported in the abstract
Sex-specific DEPs vs controls
PsA males
741
events
PsA females
31
events
Observational data: associations, not effects.
Further findings
Sex-specific multi-biomarker models discriminating PsA from controls
- AUC, all models, both sexes
- 0.85-0.99
- Significant predictor in PsA females vs controls: leukotriene A-4 hydrolase
- Significant predictors in PsA males vs controls: IL-36 alpha, NEK7 and PIK3CA/PIK3R1
Original publication
Sex differences in serum proteomic profiles in psoriatic arthritis. Rheumatology (Oxford). Published 25 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →