Sex Differences in Rheumatoid Arthritis: New Insights From Clinical and Patient-Reported Outcome Perspectives
Primary result · Disease activity (DAS44) over timeResult — go to the resultβ 0.36 95% CI 0.25–0.47Authors' conclusion
Nevertheless, female patients with RA have higher disease activity, a greater need for bDMARDs-although these have lower efficacy-and more functional impairment over time
Study context
- Population
- Patients with rheumatoid arthritis (RA) (1987 and/or 2010 criteria) from the Treatment in the Rotterdam Early Arthritis Cohort (tREACH)
- Participants
- 286 vs 139
- Comparison
- Female vs male patients with RA
- Femalen = 286
- Malen = 139reference
- Primary endpoint
- Clinical outcomes (disease activity, medication usage, SDFR, radiographic progression) and patient-reported outcomes (PROs) over time
Methodological detailsstratified, single-blinded, treat-to-target, fixed medication protocol, mixed models adjusted for age, initial treatment and DAS44
- Stratified
- Single-blinded
- Treat-to-target
- Fixed medication protocol
- Mixed models adjusted for age, initial treatment and DAS44
Primary result
Disease activity (DAS44) over time
β
0.36
95% CI 0.25–0.47
P < 0.001
As reported in the abstract
Further findings
Use of bDMARDs · over time · more treatment adjustments in female patients
P < 0.001
SDFR and radiographic progression
- No differences found between female and male patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex Differences in Rheumatoid Arthritis: New Insights From Clinical and Patient-Reported Outcome Perspectives. J Rheumatol. Published 1 March 2025. doi:10.
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