Responsiveness and sensitivity of patient-reported outcome measures (PROMs) to change in disease activity status in early and established rheumatoid arthritis
Authors' conclusion
HAQ-DI, morning stiffness severity, EQ-5D, general health and joint pain are responsive to disease activity status alterations on a group level in both early and established RA. For the individual patient the responsiveness of these PROMs is poor.
Study context
- Population
- Patients with early RA (tREACH trial) and established RA (TARA trial)
- Participants
- 557 vs 188
- Comparison
- Early RA vs established RA: PROM change vs change in disease activity status
- Early RAn = 557
- Established RAn = 188
- Primary endpoint
- Responsiveness of PROMs (HAQ-DI, morning stiffness severity, EQ-5D, general health, SF-36, joint pain, fatigue, productivity loss) to changes in disease activity status (remission, low disease activity, active disease) between two consecutive visits
Methodological detailsmulticentre, single-blinded, treat-to-target, linear mixed models, standardized response means
- Multicentre
- Single-blinded
- Treat-to-target
- Linear mixed models
- Standardized response means
Primary result
As reported in the abstract
PROM responsiveness to disease activity status change
- HAQ Disability Index (HAQ-DI), morning stiffness severity, general health, EQ-5D and joint pain responsive to improvement or worsening of disease activity status in both early and established RA
- Short form (SF-36) physical and mental component scale, fatigue and productivity loss not responsive in both groups
- Across nearly all PROMs, magnitude of change and proportion of individual observations reflecting a shift from and to active disease remained low
Original publication
Responsiveness and sensitivity of PROMs to change in disease activity status in early and established rheumatoid arthritis. Rheumatology (Oxford). Published 4 April 2024. doi:10.
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