Vasculitis & polymyalgia rheumatica
Serum soluble interleukin-7 receptor alpha levels are negatively correlated with the simultaneous activity of antineutrophil cytoplasmic antibody-associated vasculitis
Authors' conclusion
This study demonstrated that not only serum sIL-7Rα levels but also the populations of CD3+ and CD3+CD8+ T cells expressing m IL-7Rα were negatively correlated with simultaneous BVAS in patients with AAV.
Study context
- Population
- Patients with AAV
- Participants
- 60 AAV patients
- Comparison
- AAV patients at early high BVAS vs late low BVAS, and vs healthy controls
- Outcome
- Serum sIL-7Rα levels in relation to simultaneous AAV activity (BVAS)
Methodological detailslongitudinal paired sampling at two time points (early high and late low BVAS), healthy controls
- Longitudinal paired sampling at two time points (early high and late low BVAS)
- Healthy controls
Main finding
As reported in the abstract
Serum sIL-7Rα levels
- Serum sIL-7Rα significantly lower at early high BVAS than at late low BVAS; levels increased as BVAS decreased
- Serum sIL-7Rα inversely correlated with BVAS, ESR and CRP
- Serum sIL-7Rα at early high BVAS significantly lower than in healthy controls
Further findings
CD3+ and CD3+CD8+ T cells expressing mIL-7Rα
- Significantly increased populations at early high BVAS vs late low BVAS
Original publication
Serum soluble interleukin-7 receptor alpha levels are negatively correlated with the simultaneous activity of antineutrophil cytoplasmic antibody-associated vasculitis. Clin Exp Rheumatol. Published 25 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →