Vasculitis & polymyalgia rheumatica
PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis
Authors' conclusion
Combined cranial and extracranial PET/CT showed very high diagnostic accuracy for the diagnosis of GCA.
Study context
- Population
- Patients with suspected GCA who had not started GC >72 h previously; GCA diagnosis retained after ≥6 months of follow-up if no other diagnosis and remission after ≥6 consecutive months of treatment
- Comparison
- Cranial PET/CT vs extracranial PET/CT vs combined cranial and extracranial PET/CT for diagnosis of GCA
- Outcome
- Diagnostic performance of cranial PET/CT for GCA
Methodological detailsprospective, digital PET/CT
- Prospective
- Digital PET/CT
Performance
As reported in the abstract
Diagnostic performance for GCA
| Test or model | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|
| Cranial PET/CT | 73.3% | 97.2% | 91.7% | 89.7% |
| Extracranial PET/CT | 66.7% | 80.6% | 58.8% | 85.3% |
| Cranial + extracranial PET/CT | 80% | 77.8% | 60% | 90.3% |
Sensitivity
Cranial PET/CT73.3%
Extracranial PET/CT66.7%
Cranial + extracranial PET/CT80%
Specificity
Cranial PET/CT97.2%
Extracranial PET/CT80.6%
Cranial + extracranial PET/CT77.8%
PPV
Cranial PET/CT91.7%
Extracranial PET/CT58.8%
Cranial + extracranial PET/CT60%
NPV
Cranial PET/CT89.7%
Extracranial PET/CT85.3%
Cranial + extracranial PET/CT90.3%
Original publication
PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis. Rheumatology (Oxford). Published 22 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →