Vasculitis & polymyalgia rheumatica
Evidence of subclinical atherosclerosis in eosinophilic granulomatosis with polyangiitis
Authors' conclusion
Ultrasound markers of subclinical atherosclerosis are increased in EGPA patients as compared with controls, independently of traditional cardiovascular risk factors.
Study context
- Population
- Patients with eosinophilic granulomatosis with polyangiitis (EGPA) and matched controls
- Participants
- 40 vs 80
- Comparison
- EGPA patients vs matched controls
- EGPAn = 40
- Controlsn = 80reference
- Outcome
- Common carotid artery (CCA) intima-media thickness (IMT) on US
Methodological detailsmatched by age, sex and traditional cardiovascular risk factors
- Matched by age, sex and traditional cardiovascular risk factors
Main finding
As reported in the abstract
Median CCA-IMT
- EGPA vs Controls: P = 0.002
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Proportion with increased CCA-IMT and with CCA plaquesSignificantly higher in EGPA | P < 0.001 for both |
CCA-IMT vs disease duration and corticosteroid cumulative dose (within EGPA)
- CCA-IMT tended to increase with disease duration
- P = 0.034
- CCA-IMT tended to increase with corticosteroid cumulative dose
- P = 0.004
CCA-IMT vs ANCA status, other clinical features and therapies
- No significant associations
- Prevalence of traditional CV risk factors comparable in patients with vs without increased CCA-IMT
Original publication
Evidence of subclinical atherosclerosis in eosinophilic granulomatosis with polyangiitis. Rheumatology (Oxford). Published 21 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →