Serum bile salt-stimulated lipase levels associates with systemic inflammation and declines with effect of treatment in juvenile idiopathic arthritis
Authors' conclusion
Serum BSSL tracks systemic inflammatory activity and decreases with clinical improvement in JIA
Study context
- Population
- Children with juvenile idiopathic arthritis (JIA) and healthy controls
- Exposure
- Children with JIA vs healthy controls
- Outcome
- Serum BSSL concentrations
Methodological detailscase-control comparison with healthy controls, longitudinal follow-up after treatment
- Case-control comparison with healthy controls
- Longitudinal follow-up after treatment
Main finding
As reported in the abstract
Serum BSSL concentration
- Significantly higher serum bile salt-stimulated lipase (BSSL) concentrations in children with JIA than in healthy controls
- BSSL levels decreased following medical treatment
Observational data: associations, not effects.
Further findings
Correlations of BSSL with inflammatory markers and disease activity
- BSSL correlated positively with platelets, ESR and S100A8/A9
- No correlation with JADAS27
Original publication
Serum bile salt-stimulated lipase levels associates with systemic inflammation and declines with effect of treatment in juvenile idiopathic arthritis. Pediatr Rheumatol Online J. Published 12 February 2026. doi:10.
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