Baseline Clinical Features and Biomarker Profiles of the Childhood Arthritis and Rheumatology Research Alliance Systemic Juvenile Idiopathic Arthritis‐Associated Lung Disease Cohort
Authors' conclusion
The CARRA SJIA-LD Cohort exhibits distinct clinical features, higher medication burden, frequent MAS, and plasma biomarker patterns specific to SJIA-LD compared to patients with SJIA without LD.
Study context
- Population
- Patients with sJIA in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, 16 CARRA sites (SJIA-LD)16 CARRA sites
- Exposure
- SJIA-LD vs SJIA without known LD
- SJIA-LDn = 37
- SJIA WITHOUT LDn = 928reference
- Outcome
- Baseline characteristics and biomarker profiles
- Follow-up
- Baseline
Methodological detailsregistry-based, multicentre, cluster analysis, Lung disease-specific data via standardized case report form (REDCap Cloud); plasma biomarkers by custom Luminex panel
- Registry-based
- Multicentre
- Cluster analysis
- Lung disease-specific data via standardized case report form (REDCap Cloud); plasma biomarkers by custom Luminex panel
Main finding
As reported in the abstract
baseline
- SJIA-LD significantly younger at disease onset
- SJIA-LD more likely of Asian descent
- Higher medication burden in SJIA-LD
- SJIA-LD had higher levels of multiple lung injury biomarkers, cytokines and chemokines vs active and inactive SJIA without LD and healthy controls
- Cluster analysis proposed three SJIA-LD groups with distinct biomarker patterns (proinflammatory cytokines, type II chemokines, markers of MAS)
Observational data: associations, not effects.
Original publication
Baseline Clinical Features and Biomarker Profiles of the Childhood Arthritis and Rheumatology Research Alliance Systemic Juvenile Idiopathic Arthritis‐Associated Lung Disease Cohort. Arthritis Care Res (Hoboken). Published 10 February 2026. doi:10.
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