Serum and urinary soluble CD163 in children with active lupus nephritis
Authors' conclusion
Both sCD163 levels were associated with LN activity and differed from levels in extrarenal SLE and non-inflammatory CKD, suggesting that sCD163 may serve as a potential biomarker of kidney inflammation in pediatric SLLE patients.
Study context
- Population
- Children with active lupus nephritis (LN), systemic lupus erythematosus (SLE) with active extrarenal disease, non-lupus chronic kidney disease (CKD) and healthy matched controls4 equal groups
- Participants
- 60 children
- Exposure
- Active LN vs SLE non-LN with active extrarenal disease vs non-lupus CKD vs healthy matched controls
- Outcome
- Serum and urinary sCD163 levels (ELISA) and their association with clinical and laboratory markers of SLE activity
Methodological detailsfour groups, healthy matched controls
- Four groups
- Healthy matched controls
Main finding
As reported in the abstract
- Serum and urinary soluble CD163 (sCD163) differed significantly among groups, highest in active LN
- Renal BILAG A or B had significantly higher sCD163 than BILAG E; no significant differences across histopathological classes
- Serum sCD163 correlated negatively with eGFR and positively with proteinuria
- Urinary sCD163 correlated positively with SLEDAI, proteinuria and prednisolone dose
- No significant correlation between serum and urinary sCD163
Observational data: associations, not effects.
Further findings
Discrimination of renal vs extrarenal SLE activity and LN vs non-inflammatory CKD (serum and urinary sCD163)
- AUC, complete separation between groups
- 1
Original publication
Serum and urinary soluble CD163 in children with active lupus nephritis. Pediatr Rheumatol Online J. Published 24 March 2026. doi:10.
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