Lupus & antiphospholipid syndrome
Second delivery rates and recurrence of adverse pregnancy outcomes in women with systemic lupus erythematosus: a nationwide population-based cohort study
Main finding · Second delivery, incidence rate per 1000 person-yearsResult — go to the resultAdjusted hazard ratio 0.89 95% CI 0.80–0.99Authors' conclusion
Women with SLE have a lower rate of a second delivery and a higher recurrence risk of APOs
Study context
- Population
- Women with a first singleton liveborn delivery, Swedish registers; first delivery 2003–2020, follow-up to end of 2021median follow-up 2.3 years
- Participants
- 543 vs 17,218
- Exposure
- Women with SLE vs matched general obstetric population
- SLEn = 543
- Comparatorsn = 17,218reference
- Outcome
- Rate of a second delivery
Methodological detailsmatched (up to ten non-SLE comparators) on birth year and residence, Swedish registers, Cox proportional hazards models, modified Poisson models
- Matched (up to ten non-SLE comparators) on birth year and residence
- Swedish registers
- Cox proportional hazards models
- Modified Poisson models
Main finding
As reported in the abstract
Second delivery, incidence rate per 1000 person-years
Adjusted hazard ratio
0.89
95% CI 0.80–0.99
By group
SLEvs Comparators
aHR 0.89 (95% CI 0.80–0.99)
Observational data: associations, not effects.
Further findings
| Outcome | RR |
|---|---|
| Recurrence of preeclampsia | 1.38 |
| Recurrence of preterm delivery | 2.31 |
| Recurrence of any APO | 1.54 |
Second delivery in women with ≥1 APO in the first pregnancy (subgroup)
- Adjusted HR for second delivery among women with ≥1 APO in the first pregnancy
- 0.78 (0.63-0.96)
Original publication
Second delivery rates and recurrence of adverse pregnancy outcomes in women with systemic lupus erythematosus: a nationwide population-based cohort study. Rheumatology (Oxford). Published 7 May 2026. doi:10.
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